James L. Kilgore
Visiting Faculty
Organic and Bioorganic Chemistry

626/ 817-0883
j.kilgore@oak-crest.org

B.S., U.C. Berkeley, 1977, Chemistry
Ph.D., University of Minnesota, Minneapolis, 1984, Organic Chemistry
Postgraduate research:  University of Munich, Worcester Foundation for Experimental Biology (enzyme mechanisms, RNA and DNA synthesis)
Industrial experience: Procyon Pharmaceuticals, Cortex Pharmaceuticals, BioCatalytics, Inc. (fine chemicals, pharmaceutical synthesis and enzyme technology)

Principal Research Interests

  • Organic synthesis (heterocycles, phosphorus and silicon compounds, oligonucleotides, amino acids, drug conjugates)
  • Metabolism of xenobiotic compounds , such as drugs and environmental contaminants, by microorganisms  and mamalian enzymes
  • Development of analytical methods for biochemical and environmental applications (HPLC, LC/MS, GC/MS)
  • Bioprocessing of small molecules using isolated enzymes and microorganisms
  • Expression of cloned enzymes from native genes and methods for improving enzyme production by microbial cultures

Representative Publications
  1.  "Nickel(0)-Mediated Coupling of Imines.” Graet, A.; Sinault, L.; Seu, C.; Kilgore, J.L.; Baum, M.B. (in preparation)
  2. "Effect of Nickel and Heating Rate on Pyrolysis of N,N-Ethylene-bis-Stearamide in Iron/
    Graphite Solid Matrix.” Poskrebyshev, G.A.; Moss, J.A.; Kilgore, J.L.; Apelian, D.; Levée, P. (in preparation)
  3. Composition for the Oxidative Treatment of Hair or Skin, Fixative Composition and Method for
    Permanent Deformation of Hair.” Cassier, T.; Lauscher, D.; Schreiber, B.; Kilgore, J.; Allwhon,
    J. WO 2004/039510 (US appl 20070092471) 
  4. "Production of Amino Acids and Amino Acid Derivatives Bearing Isotopic Hydrogen Labels." Kilgore, J.L. U.S. Patent 5,254,730 (1993)
  5. "Biosynthesis of Estrogens. Estr-5-(10)-ene-3,17-dione: Isolation, Metabolism and
    Mechanistic Implications." Dharmaratne, H.R.W.; Kilgore, J.L.; Roitman, E.; Shackleton,
    C.R.; Caspi, E. J. Chem. Soc., Perkin Trans. I, 1993, 1529-1535.
  6. "Lysine 2,3-Aminomutase: Role of S-Adenosylmethionine in the Mechanism. Demonstration
    of Tritium Transfer from (2RS,3RS)-[3H]lysine to S-Adenosyl- Methionine." Kilgore, J.L.;
    and Aberhart, D.J. J. Chem. Soc., Perkin Trans. I, 1991, 79-84