Thomas J. Smith
Visiting Faculty
Biomedicine

626/ 817-0883
t.smith@oak-crest.org

M.D., University of Toronto, 1975
FRCS, Moorfields Eye Hospital, London, 1980-83
Howe Laboratory, Harvard University, 1984
Professor of Ophthalmology, University of Kentucky, 1994-pres.

Principal Research Interests

Sustained release drug delivery in ophthalmology and in the treatment of:

  • HIV/AIDS

  • Parkinson’s disease

  • Arthritis

  • Schizophrenia

Representative Publications

  1. Collins JF, Gaster RN, Krol W F, Colling CL, Kirk GF, Smith TJ. A comparison of anterior chamber and posterior chamber intraocular lenses after vitreous presentation during cataract surgery: the Department of Veterans Affairs Cooperative Cataract Study. Am. J. Ophthalmol. 2003. 136 (1) p.1-9.
  2. The Ganciclovir Implant Study Group. Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant. N. Engl. J. Med. 1997. 337 (2) p.83-90.

  3. Smith, T. Ashton P. Sustained-release subconjunctival 5-fluorouracil. Ophthalmic Surg. Lasers, 1996. 27(9): p. 763-7.
  4. Anand, R, Nightingale SD, Fish H, Smith TJ, Ashton P. Control of cytomegalovirus retinitis using sustained release of intraocular ganciclovir. Arch. Ophthalmol., 1993. 111(2): p. 223-7.
  5. Sanborn, GE, Anand R, Torti RE, Nightingale SD, Cal SX, Yates B, Ashton P, Smith TJ. Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Use of an intravitreal device. Arch. Ophthalmol., 1992. 110(2): p. 188-95.
  6. Smith, TJ, Pearson PA, Blandford DL, Brown JD, Goins KA, Hollins JL, Schmeisser ET, Glavinos P, Baldwin LB, Ashton P. ., Intravitreal sustained-release ganciclovir. Arch. Ophthalmol., 1992. 110(2): p. 255-8.
  7. Blandford DL, Smith TJ, Brown JD, Pearson PA, Ashton P. Subconjunctival sustained release 5-fluorouracil. Invest. Ophthalmol. Vis. Sci., 1992. 33(12): p. 3430-5.
  8. Ashton, P, Brown JD, Pearson PA, Blandford DL, Smith TJ, Anand R, Nightingale SD, Sanborn GE., Intravitreal ganciclovir pharmacokinetics in rabbits and man. J. Ocul. Pharmacol., 1992. 8(4): p. 343-7.
  9. Gussler, J., Aston P, Van Meter WS, Smith TJ. Collagen Shield Delivery of Trifuorothymidine. J. Cataract. Refract. Surg., 1990. 16(6): p. 719-22.
  10. Smith TJ, Maurin MB, Milosovich SM, Hussain AA.. Polyvinyl alcohol membrane permeability characteristics of 5-fluorouracil. J. Ocul. Pharmacol. 1988 4: p.147-52.