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Marc M. Baum

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Senior Faculty

Organometallic & Environmental Chemistry

[email protected]

B.Sc., Imperial College, London, 1988, Chemistry

Ph.D., Imperial College, London, 1991, Organic Chemistry

 

 

Principal Research Interests

  • Pharmacokinetics and Pharmacodynamics of antiretroviral agents for HIV prophylaxis
  • Microbial dynamics in specialized niches
  • Innovative & practical sustained release drug delivery systems
  • Catalytic carbon dioxide activation and chemical fixation
  • Atmospheric inputs & processes

Representative Publications

  • Churchman, S. A.; Moss, J. A.; Baum, M. M., Accurate Measurement of Female Genital Tract Fluid Dilution in Cervicovaginal Lavage Samples. J. Chromatogr. B 2016, 1017, 75–81.
  • Baum, M. M.; Butkyavichene, I.; Churchman, S. A.; Lopez, G.; Miller, C. S.; Smith, T. J.; Moss, J. A., An Intravaginal Ring for the Sustained Delivery of Tenofovir Disoproxil Fumarate. Int. J. Pharm. 2015, 495 (1), 579-587.
  • Pyles, R. B.; Moss, J. A.; Baum, M. M., Vaginal Mucosal HIV Prep: Fundamental Insights and Practical Considerations. In Frontiers in Clinical Drug Research: HIV, Atta-ur-Rahman, Ed. Bentham Science Publishers: Oak Park, IL, 2015; pp 33-165.
  • Gunawardana, M.; Hyde, E. R.; Lahmeyer, S.; Dorsey, B. L.; La Val, T. P.; Mullen, M.; Yoo, J.; Knight, R.; Baum, M. M., Euphorbia Plant Latex Is Inhabited by Diverse Microbial Communities. Am. J. Bot. 2015, 102 (12), 1966-1977.
  • Gunawardana, M.; Remedios-Chan, M.; Miller, C. S.; Fanter, R.; Yang, F.; Marzinke, M. A.; Hendrix, C. W.; Beliveau, M.; Moss, J. A.; Smith, T. J.; Baum, M. M., Pharmacokinetics of Long-acting Tenofovir Alafenamide (GS-7340) Subdermal Implant for HIV Prophylaxis. Antimicrob. Agents Chemother. 2015, 59 (7), 3913-3919.
  • Cortez, J. M., Jr.; Quintero, R.; Moss, J. A.; Beliveau, M.; Smith, T. J.; Baum, M. M., Pharmacokinetics of Injectable, Long-acting Nevirapine for HIV Prophylaxis in Breastfeeding Infants. Antimicrob. Agents Chemother. 2014, 59, 59-66.
  • Wu, S.; Li, X.; Gunawardana, M.; Maguire, K.; Guerrero-Given, D.; Schaudinn, C.; Wang, C.; Baum, M. M.; Webster, P., Beta-lactam Antibiotics Stimulate Biofilm Formation in Non-Typeable Haemophilus influenzae by Up-regulating Carbohydrate Metabolism. PLoS One 2014, 9 (7), e99204.
  • Moss, J. A.; Srinivasan, P.; Smith, T. J.; Butkyavichene, I.; Lopez, G.; Brooks, A. A.; Martin, A.; Dinh, C. T.; Smith, J. M.; Baum, M. M., Pod-intravaginal Rings Delivering Antiretroviral Combinations for HIV Prophylaxis: Pharmacokinetics and Preliminary Safety in a Macaque Model. Antimicrob. Agents Chemother. 2014, 58 (9), 5125-5135.
  • Wu, S.; Baum, M. M.; Kerwin, J.; Guerrero, D.; Webster, S.; Schaudinn, C.; VanderVelde, D.; Webster, P., Biofilm-specific extracellular matrix proteins of non-typeable Haemophilus influenzae. Pathog. Dis. 2014, 72 (3), 143-160.
  • Gunawardana, M.; Chang, S.; Jimenez, A.; Holland-Moritz, D.; Holland-Moritz, H.; La Val, T. P.; Lund, C.; Mullen, M.; Olsen, J.; Sztain, T. A.; Yoo, J.; Moss, J. A.; Baum, M. M.., Isolation of PCR Quality Microbial Community DNA from Heavily Contaminated Environments. J. Microbiol. Methods 2014, 102, 1-7.
  • Pyles, R. B.; Vincent, K. L.; Baum, M. M.; Elsom, B.; Miller, A. L.; Maxwell, C.; Eaves-Pyles, T. D.; Li, G.; Popov, V. L.; Nusbaum, R. J.; Ferguson, M. R., Cultivated Vaginal Microbiomes Alter HIV-1 Infection and Antiretroviral Efficacy in Colonized Epithelial Multilayer Cultures. PLoS One 2014, 9, e93419.
  • Gunawardana, M.; Mullen, M.; Yoo, J.; Webster, P.; Moss, J. A.; Baum, M. M., Sustained Delivery of Commensal Bacteria from Pod-intravaginal Rings. Antimicrob. Agents Chemother. 2014, Epub ahead of print Feb. 3.
  • Barge, L. M.; Kee, T. P.; Doloboff, I. J.; Hampton, J. M. P.; Ismail, M.; Pourkashanian, M.; Zeytounian, J.; Baum, M. M.; Moss, J. A.; Lin, C.-K.; Kidd, R. D.; Kanik, I., The Fuel Cell Model of Abiogenesis: A New Approach to Origin-of-Life Simulations. Astrobiology 2014, 14, 254-270.
  • Ursell, L. K.; Gunawardana, M.; Chang, S.; Mullen, M.; Moss, J. A.; Herold, B. C.; Keller, M. J.; McDonald, D.; González Peña, A.; Knight, R.; Baum, M. M., Comparison of the Vaginal Microbial Communities in HSV-2 Seropositive Women Receiving Medicated Intravaginal Rings. Antiviral Res. 2014, 102, 87-94.
  • Barge, L. M.; Doloboff, I. J.; Russell, M. J.; Vandervelde, D.; White, L. M.; Stucky, G. D.; Baum, M. M.; Zeytounian, J.; Kidd, R. D.; Kanik, I., Pyrophosphate Synthesis in Iron Mineral Films and Membranes Simulating Prebiotic Submarine Hydrothermal Precipitates. Geochim. Cosmochim. Acta 2014, 128C, 1-12.
  • Moss, J. A.; Baum, M. M. In Drug Delivery and Development of Anti-HIV Microbicides; das Neves, J., Sarmento, B., Eds.; Pan Stanford Publishing: Singapore, 2014.
  • Baum, M. M.; Gunawardana, M.; Webster, P., Experimental Approaches to Investigating the Vaginal Biofilm Microbiome. Methods Mol. Biol. 2014, 1147-1185.
  • Gunawardana, M.; Mullen, M.; Moss, J. A.; Pyles, R. B.; Nusbaum, R. J.; Patel, J.; Vincent, K. L.; Wang, C.; Guo, C.; Yuan, Y.-C.; Warden, C. D.; Baum, M. M., Global Expression of Molecular Transporters in the Human Vaginal Tract: Implications for HIV Chemoprophylaxis. PLoS One 2013, 8, e77340. PMCID: PMC3797116.
  • Moss, J. A.; Malone, A. M.; Smith, T. J.; Kennedy, S.; Nguyen, C.; Vincent, K. L.; Motamedi, M.; Baum, M. M., Pharmacokinetics of a Multipurpose Pod-intravaginal Ring Simultaneously Delivering Five Drugs in the Ovine Model. Antimicrob. Agents Chemother. 2013, 57, 3994-3997. PMCID: PMC3719699.
  • Moss, J. A.; Malone, A. M.; Smith, T. J.; Kennedy, S.; Kopin, E.; Nguyen, C.; Gilman, J.; Butkyavichene, I.; Vincent, K. L.; Motamedi, M.; Friend, D. R.; Clark, M. R.; Baum, M. M., Simultaneous Delivery of Tenofovir and Acyclovir via an Intravaginal Ring. Antimicrob. Agents Chemother. 2012, 56, 875-882. PMCID: PMC3264253.
  • Moss, J. A.; Malone, A. M.; Smith, T. J.; Butkyavichene, I.; Cortez, C.; Gilman, J.; Kennedy, S.; Kopin, E.; Nguyen, C.; Sinha, P.; Hendry, R. M.; Guenthner, P.; Holder, A.; Martin, A.; McNicholl, J.; Mitchell, J.; Pau, C.-P.; Srinivasan, P.; Smith, J. M.; Baum, M. M., Safety and Pharmacokinetics of Intravaginal Rings Delivering Tenofovir in Pig-tailed Macaques. Antimicrob. Agents Chemother. 2012, 56, 5952-5960. PMCID: PMC3486594.
  • Moss, J. A.; Baum, M. M.; Malone, A. M.; Kennedy, S.; Kopin, E.; Nguyen, C.; Gilman, J.; Butkyavichene, I.; Willis, R.; Vincent, K. L.; Motamedi, M.; Smith, T. J., Tenofovir and Tenofovir Disoproxil Pharmacokinetics from Intravaginal Rings. AIDS 2012, 26, 707-710. PMCID: PMC3855348.
  • Keller, M. J.; Malone, A. M.; Carpenter, C. A.; Lo, Y.; Huang, M.; Corey, L.; Willis, R.; Nguyen, C.; Kennedy, S.; Gunawardana, M.; Guerrero, D.; Moss, J. A.; Baum, M. M.; Smith, T. J.; Herold, B. C., Safety and Pharmacokinetics of Acyclovir in Women Following Release From a Silicone Elastomer Vaginal Ring. J. Antimicrob. Chemother. 2012, 67, 2005-2012. PMCID: PMC3394441.
  • Baum, M. M.; Butkyavichene, I.; Gilman, J.; Kennedy, S.; Kopin, E.; Malone, A. M.; Nguyen, C.; Smith, T. J.; Friend, D. R.; Clark, M. R.; Moss, J. A., An Intravaginal Ring for the Simultaneous Delivery of Multiple Drugs. J. Pharm. Sci. 2012, 101, 2833-2843. PMCID: PMC3857731.
  • Key, D.; Stihle, J.; Petit, J.-E.; Bonnet, C.; Depernon, L.; Liu, O.; Kennedy, S.; Latimer, R.; Burgoyne, M.; Wanger, D.; Webster, A.; Casunuran, S.; Hidalgo, S.; Thomas, M.; Moss, J. A.; Baum, M. M., Integrated Method for the Measurement of Trace Nitrogenous Atmospheric Bases. Atmos. Meas. Tech. 2011, 4, 2795-2807.
  • Hoffmann, M. R.; Moss, J. A.; Baum, M. M., Artificial Photosynthesis: Semiconductor Photocatalytic Fixation of CO2 to Afford Higher Organic Compounds. Dalton Trans. 2011, 40, 5151–5158.
  • Gunawardana, M.; Moss, J. A.; Smith, T. J.; Kennedy, S.; Kopin, E.; Nguyen, C.; Malone, A. M.; Rabe, L.; Schaudinn, C.; Webster, P.; Srinivasan, P.; Sweeney, E. D.; Smith, J. M.; Baum, M. M., Microbial Biofilms on the Surface of Intravaginal Rings Worn in Non-human Primates. J. Med. Microbiol. 2011, 60, 828-837. PMCID: PMC3167919.
  • Graet, A.; Sinault, L.; Fusaro, M. B.; Vallet, A. L.; Seu, C.; Kilgore, J. L.; Baum, M. M., Reactivity of the Nickel(0)-CO2-Imine System: New Pathway to Vicinal Diamines. Organometallics 2010, 29, 1997-2000.
  • Baum, M. M.; Kainović, A.; O’Keeffe, T.; Pandita, R.; McDonald, K.; Wu, S.; Webster, P., Characterization of Structures in Biofilms Formed by a Pseudomonas fluorescens Isolated from Soil. BMC Microbiol. 2009, 9, 103. PMCID: PMC2697165.
  • Baum, M. M.; Moss, J. A.; Pastel, S. H.; Poskrebyshev, G. A., Hydrogen Cyanide Exhaust Emissions from In-use Motor Vehicles. Environ. Sci. Technol. 2007, 41, 857-862. PMID: 17328194.
  • Baum, M. M.; Krider, E. S.; Moss, J. A., Accessible Research Experiences: A New Paradigm for In-lab Chemical Education. J. Chem. Educ. 2006, 83 (12), 1784-1787.
  • Baum, M. M.; Kiyomiya, E. S.; Kumar, S.; Lappas, A. M.; Kapinus, V. A.; Lord, H. C., III, Multi-Component Remote Sensing of Vehicle Exhaust by Dispersive Absorption Spectroscopy. 2. Direct On-road Ammonia Measurements. Environ. Sci. Technol. 2001, 35, 3735-3741. PMID: 11783653.