Marc M. Baum

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Senior Faculty

Organometallic & Environmental Chemistry

m.baum@oak-crest.org

B.Sc., Imperial College, London, 1988, Chemistry

Ph.D., Imperial College, London, 1991, Organic Chemistry

Principal Research Interests

Pharamacokinetics and Pharmacodynamics of antiretroviral agents for HIV prophylaxis
Microbial dynamics in specialized niches
Codrug design & synthesis for the prevention & management of infectious diseases
Innovative & practical sustained release drug delivery systems
Catalytic carbon dioxide activation and chemical fixation
Atmospheric inputs & processes

Representative Publications

Churchman, S. A.; Moss, J. A.; Baum, M. M., Accurate Measurement of Female Genital Tract Fluid Dilution in Cervicovaginal Lavage Samples. J. Chromatogr. B 2016, 1017, 75–81.
Baum, M. M.; Butkyavichene, I.; Churchman, S. A.; Lopez, G.; Miller, C. S.; Smith, T. J.; Moss, J. A., An Intravaginal Ring for the Sustained Delivery of Tenofovir Disoproxil Fumarate. Int. J. Pharm. 2015, 495 (1), 579-587.
Pyles, R. B.; Moss, J. A.; Baum, M. M., Vaginal Mucosal HIV Prep: Fundamental Insights and Practical Considerations. In Frontiers in Clinical Drug Research: HIV, Atta-ur-Rahman, Ed. Bentham Science Publishers: Oak Park, IL, 2015; pp 33-165.
Gunawardana, M.; Hyde, E. R.; Lahmeyer, S.; Dorsey, B. L.; La Val, T. P.; Mullen, M.; Yoo, J.; Knight, R.; Baum, M. M., Euphorbia Plant Latex Is Inhabited by Diverse Microbial Communities. Am. J. Bot. 2015, 102 (12), 1966-1977.
Gunawardana, M.; Remedios-Chan, M.; Miller, C. S.; Fanter, R.; Yang, F.; Marzinke, M. A.; Hendrix, C. W.; Beliveau, M.; Moss, J. A.; Smith, T. J.; Baum, M. M., Pharmacokinetics of Long-acting Tenofovir Alafenamide (GS-7340) Subdermal Implant for HIV Prophylaxis. Antimicrob. Agents Chemother. 2015, 59 (7), 3913-3919.
Cortez, J. M., Jr.; Quintero, R.; Moss, J. A.; Beliveau, M.; Smith, T. J.; Baum, M. M., Pharmacokinetics of Injectable, Long-acting Nevirapine for HIV Prophylaxis in Breastfeeding Infants. Antimicrob. Agents Chemother. 2014, 59, 59-66.
Wu, S.; Li, X.; Gunawardana, M.; Maguire, K.; Guerrero-Given, D.; Schaudinn, C.; Wang, C.; Baum, M. M.; Webster, P., Beta-lactam Antibiotics Stimulate Biofilm Formation in Non-Typeable Haemophilus influenzae by Up-regulating Carbohydrate Metabolism. PLoS One 2014, 9 (7), e99204.
Moss, J. A.; Srinivasan, P.; Smith, T. J.; Butkyavichene, I.; Lopez, G.; Brooks, A. A.; Martin, A.; Dinh, C. T.; Smith, J. M.; Baum, M. M., Pod-intravaginal Rings Delivering Antiretroviral Combinations for HIV Prophylaxis: Pharmacokinetics and Preliminary Safety in a Macaque Model. Antimicrob. Agents Chemother. 2014, 58 (9), 5125-5135.
Wu, S.; Baum, M. M.; Kerwin, J.; Guerrero, D.; Webster, S.; Schaudinn, C.; VanderVelde, D.; Webster, P., Biofilm-specific extracellular matrix proteins of non-typeable Haemophilus influenzae. Pathog. Dis. 2014, 72 (3), 143-160.
Gunawardana, M.; Chang, S.; Jimenez, A.; Holland-Moritz, D.; Holland-Moritz, H.; La Val, T. P.; Lund, C.; Mullen, M.; Olsen, J.; Sztain, T. A.; Yoo, J.; Moss, J. A.; Baum, M. M.., Isolation of PCR Quality Microbial Community DNA from Heavily Contaminated Environments. J. Microbiol. Methods 2014, 102, 1-7.
Pyles, R. B.; Vincent, K. L.; Baum, M. M.; Elsom, B.; Miller, A. L.; Maxwell, C.; Eaves-Pyles, T. D.; Li, G.; Popov, V. L.; Nusbaum, R. J.; Ferguson, M. R., Cultivated Vaginal Microbiomes Alter HIV-1 Infection and Antiretroviral Efficacy in Colonized Epithelial Multilayer Cultures. PLoS One 2014, 9, e93419.
Gunawardana, M.; Mullen, M.; Yoo, J.; Webster, P.; Moss, J. A.; Baum, M. M., Sustained Delivery of Commensal Bacteria from Pod-intravaginal Rings. Antimicrob. Agents Chemother. 2014, Epub ahead of print Feb. 3.
Barge, L. M.; Kee, T. P.; Doloboff, I. J.; Hampton, J. M. P.; Ismail, M.; Pourkashanian, M.; Zeytounian, J.; Baum, M. M.; Moss, J. A.; Lin, C.-K.; Kidd, R. D.; Kanik, I., The Fuel Cell Model of Abiogenesis: A New Approach to Origin-of-Life Simulations. Astrobiology 2014, 14, 254-270.
Ursell, L. K.; Gunawardana, M.; Chang, S.; Mullen, M.; Moss, J. A.; Herold, B. C.; Keller, M. J.; McDonald, D.; González Peña, A.; Knight, R.; Baum, M. M., Comparison of the Vaginal Microbial Communities in HSV-2 Seropositive Women Receiving Medicated Intravaginal Rings. Antiviral Res. 2014, 102, 87-94.
Barge, L. M.; Doloboff, I. J.; Russell, M. J.; Vandervelde, D.; White, L. M.; Stucky, G. D.; Baum, M. M.; Zeytounian, J.; Kidd, R. D.; Kanik, I., Pyrophosphate Synthesis in Iron Mineral Films and Membranes Simulating Prebiotic Submarine Hydrothermal Precipitates. Geochim. Cosmochim. Acta 2014, 128C, 1-12.
Moss, J. A.; Baum, M. M. In Drug Delivery and Development of Anti-HIV Microbicides; das Neves, J., Sarmento, B., Eds.; Pan Stanford Publishing: Singapore, 2014.
Baum, M. M.; Gunawardana, M.; Webster, P., Experimental Approaches to Investigating the Vaginal Biofilm Microbiome. Methods Mol. Biol. 2014, 1147-1185.
Gunawardana, M.; Mullen, M.; Moss, J. A.; Pyles, R. B.; Nusbaum, R. J.; Patel, J.; Vincent, K. L.; Wang, C.; Guo, C.; Yuan, Y.-C.; Warden, C. D.; Baum, M. M., Global Expression of Molecular Transporters in the Human Vaginal Tract: Implications for HIV Chemoprophylaxis. PLoS One 2013, 8, e77340. PMCID: PMC3797116.
Moss, J. A.; Malone, A. M.; Smith, T. J.; Kennedy, S.; Nguyen, C.; Vincent, K. L.; Motamedi, M.; Baum, M. M., Pharmacokinetics of a Multipurpose Pod-intravaginal Ring Simultaneously Delivering Five Drugs in the Ovine Model. Antimicrob. Agents Chemother. 2013, 57, 3994-3997. PMCID: PMC3719699.
Moss, J. A.; Malone, A. M.; Smith, T. J.; Kennedy, S.; Kopin, E.; Nguyen, C.; Gilman, J.; Butkyavichene, I.; Vincent, K. L.; Motamedi, M.; Friend, D. R.; Clark, M. R.; Baum, M. M., Simultaneous Delivery of Tenofovir and Acyclovir via an Intravaginal Ring. Antimicrob. Agents Chemother. 2012, 56, 875-882. PMCID: PMC3264253.
Moss, J. A.; Malone, A. M.; Smith, T. J.; Butkyavichene, I.; Cortez, C.; Gilman, J.; Kennedy, S.; Kopin, E.; Nguyen, C.; Sinha, P.; Hendry, R. M.; Guenthner, P.; Holder, A.; Martin, A.; McNicholl, J.; Mitchell, J.; Pau, C.-P.; Srinivasan, P.; Smith, J. M.; Baum, M. M., Safety and Pharmacokinetics of Intravaginal Rings Delivering Tenofovir in Pig-tailed Macaques. Antimicrob. Agents Chemother. 2012, 56, 5952-5960. PMCID: PMC3486594.
Moss, J. A.; Baum, M. M.; Malone, A. M.; Kennedy, S.; Kopin, E.; Nguyen, C.; Gilman, J.; Butkyavichene, I.; Willis, R.; Vincent, K. L.; Motamedi, M.; Smith, T. J., Tenofovir and Tenofovir Disoproxil Pharmacokinetics from Intravaginal Rings. AIDS 2012, 26, 707-710. PMCID: PMC3855348.
Keller, M. J.; Malone, A. M.; Carpenter, C. A.; Lo, Y.; Huang, M.; Corey, L.; Willis, R.; Nguyen, C.; Kennedy, S.; Gunawardana, M.; Guerrero, D.; Moss, J. A.; Baum, M. M.; Smith, T. J.; Herold, B. C., Safety and Pharmacokinetics of Acyclovir in Women Following Release From a Silicone Elastomer Vaginal Ring. J. Antimicrob. Chemother. 2012, 67, 2005-2012. PMCID: PMC3394441.
Baum, M. M.; Butkyavichene, I.; Gilman, J.; Kennedy, S.; Kopin, E.; Malone, A. M.; Nguyen, C.; Smith, T. J.; Friend, D. R.; Clark, M. R.; Moss, J. A., An Intravaginal Ring for the Simultaneous Delivery of Multiple Drugs. J. Pharm. Sci. 2012, 101, 2833-2843. PMCID: PMC3857731.
Key, D.; Stihle, J.; Petit, J.-E.; Bonnet, C.; Depernon, L.; Liu, O.; Kennedy, S.; Latimer, R.; Burgoyne, M.; Wanger, D.; Webster, A.; Casunuran, S.; Hidalgo, S.; Thomas, M.; Moss, J. A.; Baum, M. M., Integrated Method for the Measurement of Trace Nitrogenous Atmospheric Bases. Atmos. Meas. Tech. 2011, 4, 2795-2807.
Hoffmann, M. R.; Moss, J. A.; Baum, M. M., Artificial Photosynthesis: Semiconductor Photocatalytic Fixation of CO₂ to Afford Higher Organic Compounds. Dalton Trans. 2011, 40, 5151–5158.
Gunawardana, M.; Moss, J. A.; Smith, T. J.; Kennedy, S.; Kopin, E.; Nguyen, C.; Malone, A. M.; Rabe, L.; Schaudinn, C.; Webster, P.; Srinivasan, P.; Sweeney, E. D.; Smith, J. M.; Baum, M. M., Microbial Biofilms on the Surface of Intravaginal Rings Worn in Non-human Primates. J. Med. Microbiol. 2011, 60, 828-837. PMCID: PMC3167919.
Graet, A.; Sinault, L.; Fusaro, M. B.; Vallet, A. L.; Seu, C.; Kilgore, J. L.; Baum, M. M., Reactivity of the Nickel(0)-CO₂-Imine System: New Pathway to Vicinal Diamines. Organometallics 2010, 29, 1997-2000.
Baum, M. M.; Kainović, A.; O’Keeffe, T.; Pandita, R.; McDonald, K.; Wu, S.; Webster, P., Characterization of Structures in Biofilms Formed by a Pseudomonas fluorescens Isolated from Soil. BMC Microbiol. 2009, 9, 103. PMCID: PMC2697165.
Baum, M. M.; Moss, J. A.; Pastel, S. H.; Poskrebyshev, G. A., Hydrogen Cyanide Exhaust Emissions from In-use Motor Vehicles. Environ. Sci. Technol. 2007, 41, 857-862. PMID: 17328194.
Baum, M. M.; Krider, E. S.; Moss, J. A., Accessible Research Experiences: A New Paradigm for In-lab Chemical Education. J. Chem. Educ. 2006, 83 (12), 1784-1787.
Baum, M. M.; Kiyomiya, E. S.; Kumar, S.; Lappas, A. M.; Kapinus, V. A.; Lord, H. C., III, Multi-Component Remote Sensing of Vehicle Exhaust by Dispersive Absorption Spectroscopy. 2. Direct On-road Ammonia Measurements. Environ. Sci. Technol. 2001, 35, 3735-3741. PMID: 11783653.