Featured Publications

Below are some recent publications highlighting the broad scientific impact of the Oak Crest Institute of Science. For a complete list and impact metrics, visit our institution page on Research Gate.

2023

Gallay et al.Acute Antagonism in Three-drug Combinations for Vaginal HIV Prevention in Humanized Mice. Sci. Rep. 2023, 13 (1), 4594.

Download: https://www.nature.com/articles/s41598-023-31695-5

Press release: https://healthnewswire.com/press-release/new-study-highlights-the-complexity-of-using-antiviral-drug-combinations-for-hiv-prevention-301789659/

2022

Gunawardana et al. Early SARS-CoV-2 Dynamics and Immune Responses in Unvaccinated Participants of an Intensely Sampled Longitudinal Surveillance Study. Commun. Med. 2022, 2, 129.

Download: https://www.nature.com/articles/s43856-022-00195-4.pdf

Press Release: https://www.prnewswire.com/news-releases/covid-study-of-unvaccinated-sample-puts-cutting-edge-research-on-the-map-301661067.html

https://www.labpulse.com/diseases/covid-19/article/15302237/study-of-covid19-in-unvaccinated-may-have-implications-for-testing-oak-crest-institute

Gunawardana et al. Clinical SARS-CoV-2 Kinetic Profiles Are Dependent on the Viral Strain and Host Vaccination Status. Microbiol Spectr. 2022 Dec 21;10(6):e0446922. doi: 10.1128/spectrum.04469-22. Epub 2022 Dec 1.

Download: https://journals.asm.org/doi/full/10.1128/spectrum.04469-22

Press Release: https://pharmaceuticalnewswire.com/press-release/sars-cov-2-virus-kinetics-influenced-by-viral-strain-and-vaccination-status-301696245/

Gunawardana et al. Fundamental Aspects of Long-acting Tenofovir Alafenamide Delivery from Subdermal Implants for HIV Prophylaxis. Sci. Rep. 2022, 12 (1), 8224.

Download: https://link.springer.com/content/pdf/10.1038/s41598-022-11020-2.pdf

Barge et al. Prebiotic Reactions in a Mars Analog Iron Mineral System: Effects of Nitrate, Nitrite, and Ammonia on Amino Acid Formation. Geochim. Cosmochim. Acta 2022, 336, 469-479.

Download: https://web.gps.caltech.edu/~yly/yly_mac/ReprintsYLY/N429_barge_2022_mars_iron.pdf

Han et al. Botulinum neurotoxin accurately separates tonic vs phasic transmission and reveals heterosynaptic plasticity rules in Drosophila. Elife. 2022 Aug 22;11:e77924. doi: 10.7554/eLife.77924. Epub ahead of print. PMID: 35993544.

Download:  https://elifesciences.org/articles/77924.pdf

Danese et al. Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy. Cell Rep. 2022 Jul 19;40(3):111124. doi: 10.1016/j.celrep.2022.111124. PMID: 35858578; PMCID: PMC9314546.

Download: https://doi.org/10.1016/j.celrep.2022.111124

Gengiah et al. CAPRISA 018: a phase I/II clinical trial study protocol to assess the safety, acceptability, tolerability and pharmacokinetics of a sustained-release tenofovir alafenamide subdermal implant for HIV prevention in women. BMJ Open. 2022 Jan 6;12(1):e052880. doi: 10.1136/bmjopen-2021-052880. PMID: 34992111; PMCID: PMC8739430.

Download: https://doi.org/10.1136/bmjopen-2021-052880

2021

Gunawardana et al. 2021. Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints. mSphere 2021, 6 (4), e0054221.

Download: https://journals.asm.org/doi/full/10.1128/mSphere.00542-21

Romano et al. 2021. Tenofovir Alafenamide for HIV Prevention: Review of the Proceedings from the Gates Foundation Long-Acting TAF Product Development Meeting. AIDS Res Hum Retroviruses. 2021 Jun;37(6):409-420. doi: 10.1089/AID.2021.0028. PMID: 33913760; PMCID: PMC8213003.

Download: https://doi.org/10.1089/aid.2021.0028

Bobardt et al. 2021. The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance. PLOS ONE 16(5): e0251934.

Download: https://doi.org/10.1371/journal.pone.0251934

Bao et al. 2021. Human RGR Gene and Associated Features of Age-related Macular Degeneration Revealed in Models of Retina-Choriocapillaris Atrophy. Am J Pathol. 2021 May 19:S0002-9440(21)00202-9.

Download: doi: 10.1016/j.ajpath.2021.05.003.

2020

Baum et al. 2020. Highly Synergistic Drug Combination Prevents Vaginal HIV Infection in Humanized Mice. Sci. Rep. 2020, 10 (1), 12995.

Download: https://www.nature.com/articles/s41598-020-69937-5

Aguirre et al. 2020. Synthesis and Characterization of Mixed-Valent Iron Layered Double Hydroxides (“Green Rust”). ACS Earth Space Chem. 2020, Epub ahead of print Dec. 19.

Download: https://doi.org/10.1021/acsearthspacechem.0c00272

Download: https://www.researchgate.net/profile/Paul-Webster/publication/347845032_Synthesis_and_Characterization_of_Mixed-Valent_Iron_Layered_Double_Hydroxides_Green_Rust/links/5ff8cc6c92851c13fefb23e5/Synthesis-and-Characterization-of-Mixed-Valent-Iron-Layered-Double-Hydroxides-Green-Rust.pdf

Hooks et al 2020. Effects of amino acids on iron-silicate chemical garden precipitation. 2020. Langmuir. doi.org/10.1021/acs.langmuir.0c00502

Download: https://pubs.acs.org/doi/10.1021/acs.langmuir.0c00502

Webster et al 2020. Concentrative nucleotide transporter 3 is located in microvilli on vaginal epithelial cells. ACS Omega 2020.

Download: https://dx.doi.org/10.1021/acsomega.0c02329

Webster et al 2020. Equilibrative nucleoside transporter 1 (SLC29A1) localization on vaginal epithelial cells. J. Histology & Histopathology. ISSN 2055-091X, Volume 7, Article 5. 2020

Download: https://www.researchgate.net/profile/Paul-Webster/publication/342074308_Equilibrative_nucleoside_transporter_1_slc29a1_localization_on_vaginal_epithelial_cells/links/5ef6179b299bf18816e83e95/Equilibrative-nucleoside-transporter-1-slc29a1-localization-on-vaginal-epithelial-cells.pdf

2019

Barge et al. 2019. Redox and pH Gradients Drive Amino Acid Synthesis in Iron Oxyhydroxide Mineral Systems. Proc. Natl. Acad. Sci. U.S.A. 2019, 116 (11), 4828-4833.

Download: https://www.pnas.org/doi/full/10.1073/pnas.1812098116

2018

Vincent et al. 2018. Safety and Pharmacokinetics of Single, Dual, and Triple Antiretroviral Drug Formulations Delivered by Pod-intravaginal Rings Designed for HIV-1 Prevention: A Phase I Trial. PLos Med. 2018, 15 (9).

Download: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002655

2017

Bock et al. 2017. Dicarboxylic Acid Emissions from Aftertreatment Equipped Diesel Engines. Environ. Sci. Technol. 2017, 51 (21), 13036-13043.

Download: https://doi.org/10.1021/acs.est.7b03868

Smith et al. 2017. Novel Multipurpose Pod-intravaginal Ring for the Prevention of HIV, HSV, and Unintended Pregnancy: Pharmacokinetic Evaluation in a Macaque Model. PLoS One 2017, 12 (10), e0185946.

Download: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185946

2016

Srinivasan et al. 2016. Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures. PLoS One 2016, 11 (6), e0157061.

Download: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157061

2015

Gunawardana et al. 2015. Euphorbia Plant Latex Is Inhabited by Diverse Microbial Communities. Am. J. Bot. 2015, 102 (12), 1966-1977. doi:10.3732/ajb.1500223

Download: https://bsapubs.onlinelibrary.wiley.com/doi/pdf/10.3732/ajb.1500223

Baum et al. 2015. An Intravaginal Ring for the Sustained Delivery of Tenofovir Disoproxil Fumarate. Int. J. Pharm. 2015, 495 (1), 579-587. doi: 10.1016/j.ijpharm.2015.09.028

Download: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609628/

2014

Gunawardana et al. 2014. Isolation of PCR Quality Microbial Community DNA from Heavily Contaminated Environments. J. Microbiol. Methods 2014, 102, 1-7.

Download: https://d1wqtxts1xzle7.cloudfront.net/80032190/j.mimet.2014.04.00520220131-28653-n3vamc-libre.pdf?1643674810=&response-content-disposition=inline%3B+filename%3DIsolation_of_PCR_quality_microbial_commu.pdf&Expires=1682994034&Signature=Ql-sWrfsJ0oeX26-AJC8Yngc6FQci4IW7A3B0a3zloKbrTrG3u63I1vPgIO7BYonqZ2RKOvERW44zfqf5BxY2bKnwBZ12bIYfNP4jxAt9UVQg75z6CouvYW7guFVABoOm5pPF25mpSEyH7gU3GPB-lhFduTGVsIqPUz4RBxW283CTUTB9VBTAX3xtYTRkLJ30Ll-xE~eGmm2Dj6JjM0KF2q932c0XijYhtkZF~naTnVJ-YsF9OYXFwqTvESw6GFJrkF7bC-3-KdzSZbyx9xqBUh5Jk9CK~7Ov-pbDWv5wkFoo~OC8e0IKdIBsna-rEx365sIVf5kL5M7Yq6qCFlLuA__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA

Gunawardana et al. 2014.An Intravaginal Ring for the Sustained Delivery of Antibodies. J. Pharm. Sci. 2014, 103 (11), 3611-3620. doi: 10.1002/jps.24154

Download: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206599/

Wu et al 2014. Biofilm-specific extracellular matrix proteins of non-typeable Haemophilus influenzae. Pathog Dis. 2014 Jun 19. doi: 10.1111/2049-632X.12195. PMID: 24942343.