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Chris Buser

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Senior Faculty

Electron & Atomic Force Microscopy

[email protected]

Dipl. Natw. ETH (MS); Biochemistry; Swiss Federal Institute of Technology Zurich; 2003

Ph.D.; Human Biology; University of Ulm, Germany; 2006

Postdoctoral Scholar; Molecular & Cell Biology; UC Berkeley; 2007-2011

Service specialist for electron microscopy in biomedical research; Droseran LLC; 2015-2017

Principal Research Interests

  • Application of high-resolution imaging for biomedical contract research
  • Development of preparation techniques for atomic force microscopy
  • Infectious diseases & diagnostics

Representative Publications

  • Buser C and Drubin DG. 2013. Ultrastructural imaging of endocytic sites in S. cerevisiae by transmission electron microscopy and immunolabeling. Microsc Microanal., 19(2):381-92.
  • Kishimoto T, Sun Y, Buser C, Liu J, Michelot A, Drubin DG. 2011. Determinants of endocytic membrane geometry, stability and scission. PNAS, 108(44):E979-88.
  • Buser C. 2010. Toward sub-second correlative light and electron microscopy of Saccharomyces cerevisiae. Methods Cell Biol., 96:217-34.
  • McDonald K, Schwarz H, Müller‐Reichert T, Webb R, Buser C, Morphew M. 2010. ‘Tips and tricks’ for high‐pressure freezing of model systems. Methods Cell Biol., 96:671-93.
  • Popa M, Ruzsics Z, Lötzerich M, Dölken L, Buser C, Walther P, Koszinowski UH. 2010. Dominant negative mutants of murine cytomegalovirus M53 gene block nuclear egress and inhibit capsid maturation. J Virol, 84(18):9035-46.
  • Buser C, McDonald K. 2010. Correlative GFP-immunoelectron microscopy in yeast. Methods Enzymol. 470: 603-18.
  • Chevillotte M, Landwehr S, Linta L, Frascaroli G, Lüske A, Buser C, Mertens T, von Einem J. 2008. The major tegument protein pp65 of human cytomegalovirus is required for the incorporation of pUL69 and pUL97 into the virus particle and for viral growth in macrophages. J Virol 83(6):2480-90.
  • Buser C, Walther P. 2008. Freeze-Substitution: The Addition of Water to Polar Solvents Enhances the Retention of Structure and Acts at Temperatures Around –60 °C. J Microsc 230 (Pt 2):268-77.
  • Buser C, Fleischer F, Mertens T, Michel D, Schmidt V, Walther P. 2007. Quantitative investigation of murine cytomegalovirus nucleocapsid interaction. J Microsc 228:78-87.
  • Buser C, Walther P, Mertens T, Michel D. 2007. Cytomegalovirus primary envelopment occurs at large infoldings of the inner nuclear membrane. J Virol 81:3042-8.
  • Rupp B, Ruzsics Z, Buser C, Adler B, Walther P, Koszinowski UH. 2007. A random screen for dominant-negative mutants of the cytomegalovirus nucler egress protein M50. J Virol 81:5508-17.