Featured Publications
Below are some recent publications highlighting the broad scientific impact of the Oak Crest Institute of Science. For a complete list and impact metrics, visit our institution page on Research Gate.
2023
Gallay et al.Acute Antagonism in Three-drug Combinations for Vaginal HIV Prevention in Humanized Mice. Sci. Rep. 2023, 13 (1), 4594.
Download: https://journals.asm.org/doi/epub/10.1128/spectrum.04469-22
2022
Gunawardana et al. Early SARS-CoV-2 Dynamics and Immune Responses in Unvaccinated Participants of an Intensely Sampled Longitudinal Surveillance Study. Commun. Med. 2022, 2, 129.
Download: https://www.nature.com/articles/s43856-022-00195-4.pdf
Press Release: https://www.prnewswire.com/news-releases/covid-study-of-unvaccinated-sample-puts-cutting-edge-research-on-the-map-301661067.html
Gunawardana et al. Clinical SARS-CoV-2 Kinetic Profiles Are Dependent on the Viral Strain and Host Vaccination Status. Microbiol Spectr. 2022 Dec 21;10(6):e0446922. doi: 10.1128/spectrum.04469-22. Epub 2022 Dec 1.
Press Release: https://pharmaceuticalnewswire.com/press-release/sars-cov-2-virus-kinetics-influenced-by-viral-strain-and-vaccination-status-301696245/
Gunawardana et al. Fundamental Aspects of Long-acting Tenofovir Alafenamide Delivery from Subdermal Implants for HIV Prophylaxis. Sci. Rep. 2022, 12 (1), 8224.
Download: https://link.springer.com/content/pdf/10.1038/s41598-022-11020-2.pdf
Barge et al. Prebiotic Reactions in a Mars Analog Iron Mineral System: Effects of Nitrate, Nitrite, and Ammonia on Amino Acid Formation. Geochim. Cosmochim. Acta 2022, 336, 469-479.
Download: https://web.gps.caltech.edu/~yly/yly_mac/ReprintsYLY/N429_barge_2022_mars_iron.pdf
Han et al. Botulinum neurotoxin accurately separates tonic vs phasic transmission and reveals heterosynaptic plasticity rules in Drosophila. Elife. 2022 Aug 22;11:e77924. doi: 10.7554/eLife.77924. Epub ahead of print. PMID: 35993544.
Download: https://elifesciences.org/articles/77924.pdf
Danese et al. Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy. Cell Rep. 2022 Jul 19;40(3):111124. doi: 10.1016/j.celrep.2022.111124. PMID: 35858578; PMCID: PMC9314546.
Download: https://doi.org/10.1016/j.celrep.2022.111124
Gengiah et al. CAPRISA 018: a phase I/II clinical trial study protocol to assess the safety, acceptability, tolerability and pharmacokinetics of a sustained-release tenofovir alafenamide subdermal implant for HIV prevention in women. BMJ Open. 2022 Jan 6;12(1):e052880. doi: 10.1136/bmjopen-2021-052880. PMID: 34992111; PMCID: PMC8739430.
Download: https://doi.org/10.1136/bmjopen-2021-052880
2021
Gunawardana et al. 2021. Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints. mSphere 2021, 6 (4), e0054221.
Romano et al. 2021. Tenofovir Alafenamide for HIV Prevention: Review of the Proceedings from the Gates Foundation Long-Acting TAF Product Development Meeting. AIDS Res Hum Retroviruses. 2021 Jun;37(6):409-420. doi: 10.1089/AID.2021.0028. PMID: 33913760; PMCID: PMC8213003.
Bobardt et al. 2021. The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance. PLOS ONE 16(5): e0251934.
Download: https://doi.org/10.1371/journal.pone.0251934
Bao et al. 2021. Human RGR Gene and Associated Features of Age-related Macular Degeneration Revealed in Models of Retina-Choriocapillaris Atrophy. Am J Pathol. 2021 May 19:S0002-9440(21)00202-9.
Download: doi: 10.1016/j.ajpath.2021.05.003.
2020
Baum et al. 2020. Highly Synergistic Drug Combination Prevents Vaginal HIV Infection in Humanized Mice. Sci. Rep. 2020, 10 (1), 12995.
Download: https://www.nature.com/articles/s41598-020-69937-5
Aguirre et al. 2020. Synthesis and Characterization of Mixed-Valent Iron Layered Double Hydroxides (“Green Rust”). ACS Earth Space Chem. 2020, Epub ahead of print Dec. 19.
Hooks et al 2020. Effects of amino acids on iron-silicate chemical garden precipitation. 2020. Langmuir. doi.org/10.1021/acs.langmuir.0c00502
Webster et al 2020. Concentrative nucleotide transporter 3 is located in microvilli on vaginal epithelial cells. ACS Omega 2020.
Download: https://dx.doi.org/10.1021/acsomega.0c02329
Webster et al 2020. Equilibrative nucleoside transporter 1 (SLC29A1) localization on vaginal epithelial cells. J. Histology & Histopathology. ISSN 2055-091X, Volume 7, Article 5. 2020. doi: 10.7243/2055-091X-7-5
2019
Barge et al. 2019. Redox and pH Gradients Drive Amino Acid Synthesis in Iron Oxyhydroxide Mineral Systems. Proc. Natl. Acad. Sci. U.S.A. 2019, 116 (11), 4828-4833.
Download: https://www.pnas.org/doi/full/10.1073/pnas.1812098116
2018
Vincent et al. 2018. Safety and Pharmacokinetics of Single, Dual, and Triple Antiretroviral Drug Formulations Delivered by Pod-intravaginal Rings Designed for HIV-1 Prevention: A Phase I Trial. PLos Med. 2018, 15 (9).
Download: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002655
2017
Bock et al. 2017. Dicarboxylic Acid Emissions from Aftertreatment Equipped Diesel Engines. Environ. Sci. Technol. 2017, 51 (21), 13036-13043.
Download: https://doi.org/10.1021/acs.est.7b03868
Smith et al. 2017. Novel Multipurpose Pod-intravaginal Ring for the Prevention of HIV, HSV, and Unintended Pregnancy: Pharmacokinetic Evaluation in a Macaque Model. PLoS One 2017, 12 (10), e0185946.
Download: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185946
2016
Srinivasan et al. 2016. Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures. PLoS One 2016, 11 (6), e0157061.
Download: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157061
2015
Gunawardana et al. 2015. Euphorbia Plant Latex Is Inhabited by Diverse Microbial Communities. Am. J. Bot. 2015, 102 (12), 1966-1977. doi:10.3732/ajb.1500223
Download: https://bsapubs.onlinelibrary.wiley.com/doi/pdf/10.3732/ajb.1500223
Baum et al. 2015. An Intravaginal Ring for the Sustained Delivery of Tenofovir Disoproxil Fumarate. Int. J. Pharm. 2015, 495 (1), 579-587. doi: 10.1016/j.ijpharm.2015.09.028
Download: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609628/
2014
Gunawardana et al. 2014. Isolation of PCR Quality Microbial Community DNA from Heavily Contaminated Environments. J. Microbiol. Methods 2014, 102, 1-7.
Gunawardana et al. 2014.An Intravaginal Ring for the Sustained Delivery of Antibodies. J. Pharm. Sci. 2014, 103 (11), 3611-3620. doi: 10.1002/jps.24154
Download: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206599/
Wu et al 2014. Biofilm-specific extracellular matrix proteins of non-typeable Haemophilus influenzae. Pathog Dis. 2014 Jun 19. doi: 10.1111/2049-632X.12195. PMID: 24942343.